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Journal of Sensors and Sensor Systems An open-access peer-reviewed journal
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Volume 7, issue 2
J. Sens. Sens. Syst., 7, 559-567, 2018
https://doi.org/10.5194/jsss-7-559-2018
© Author(s) 2018. This work is distributed under
the Creative Commons Attribution 4.0 License.

Special issue: Dresden Sensor Symposium 2017

J. Sens. Sens. Syst., 7, 559-567, 2018
https://doi.org/10.5194/jsss-7-559-2018
© Author(s) 2018. This work is distributed under
the Creative Commons Attribution 4.0 License.

Regular research article 29 Oct 2018

Regular research article | 29 Oct 2018

Continuous in-line monitoring of electrolyte concentrations in extracorporeal circuits for individualization of dialysis treatment

Marc Berger1, Michael Faulstich2, Thorsten Perl3, and Stefan Zimmermann1 Marc Berger et al.
  • 1Institute of Electrical Engineering and Measurement Technology, Department of Sensors and Measurement Technology, Leibniz Universität Hannover, 30167 Hannover, Germany
  • 2Department of Anesthesiology, University Göttingen, 37099 Göttingen, Germany
  • 3Departments of General-, Visceral- and Paediatric Surgery, University Göttingen, 37099 Göttingen, Germany

Abstract. One objective of dialysis treatment is to normalize the blood plasma electrolytes and remove waste products such as urea and creatinine from blood. However, due to a shift in plasma osmolarity, a rapid or excessive change of the electrolytes can lead to complications like cardiovascular instability, overhydrating of cells, disequilibrium syndrome and cardiac arrhythmias. Especially for critical ill patients in intensive care unit with sepsis or multi-organ failure, any additional stress has to be avoided. Since the exchange velocity of the electrolytes mainly depends on the concentration gradients across the dialysis membrane between blood and dialysate, it can be controlled by an individualized composition of dialysate concentrations. In order to obtain a precise concentration gradient with the individualized dialysate, it is necessary to continuously monitor the plasma concentrations. However, with in-line sensors, the required hemocompatibility is often difficult to achieve. In this work, we present a concept for continuous in-line monitoring of electrolyte concentrations using ion-selective electrodes separated from the blood flow by a dialysis membrane, and therefore meeting the fluidic requirements for hemocompatibility. First investigations of hemocompatibility with reconfigured human blood show no increased hemolysis caused by the measuring system. With this concept, it is possible to continuously measure the plasma concentrations with a relative error of less than 0.5%.

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A dialysis treatment with an individual dialysis fluid composition can prevent certain complications during treatment. For this purpose, it is necessary to know the exact electrolyte concentrations in the blood. In this work, we present a concept for continuous in-line monitoring of electrolyte concentrations using ion-selective electrodes separated from the blood flow by a dialysis membrane. First investigations of this concept show no hemolysis and a relative error of less than 0.5 %.
A dialysis treatment with an individual dialysis fluid composition can prevent certain...
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