Articles | Volume 7, issue 1
https://doi.org/10.5194/jsss-7-101-2018
Special issue:
https://doi.org/10.5194/jsss-7-101-2018
Regular research article
 | 
23 Feb 2018
Regular research article |  | 23 Feb 2018

Design and evaluation of split-ring resonators for aptamer-based biosensors

Tobias Reinecke, Johanna-Gabriela Walter, Tim Kobelt, André Ahrens, Thomas Scheper, and Stefan Zimmermann

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Cited articles

Akerlof, G.: Dielectric constants of some organic solvent-water mixtures at various temperatures, J. Am. Chem. Soc., 54, 4125–4139, https://doi.org/10.1021/ja01350a001, 1932.
Albishi, A. and Ramahi, O. M.: Detection of surface and subsurface cracks in metallic and non-metallic materials using a complementary split-ring resonator, Sensors (Basel, Switzerland), 14, 19354–19370, https://doi.org/10.3390/s141019354, 2014.
Ebrahimi, A., Withayachumnankul, W., Al-Sarawi, S., and Abbott, D.: High-Sensitivity Metamaterial-Inspired Sensor for Microfluidic Dielectric Characterization, IEEE Sensors J., 14, 1345–1351, https://doi.org/10.1109/JSEN.2013.2295312, 2014.
Heilkenbrinker, A., Reinemann, C., Stoltenburg, R., Walter, J.-G., Jochums, A., Stahl, F., Zimmermann, S., Strehlitz, B., and Scheper, T.: Identification of the target binding site of ethanolamine-binding aptamers and its exploitation for ethanolamine detection, Anal. Chem., 87, 677–685, https://doi.org/10.1021/ac5034819, 2015.
Huang, Y. and Boyle, K.: Antennas, From theory to practice, Chichester, Wiley, 2008.
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Short summary
A systematic investigation of a split-ring resonator for application as a biosensor is presented. The parameters responsible for the sensitivity of the setup were determined using a new approach to determine the resonance frequency depending on the relative permittivity of the sample. Based on these parameters, the resonator structure was optimized. Subsequently, a split-ring resonator was functionalized with aptamers and a selective detection of CRP could be shown.
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