Journal cover Journal topic
Journal of Sensors and Sensor Systems An open-access peer-reviewed journal
J. Sens. Sens. Syst., 7, 101-111, 2018
© Author(s) 2018. This work is distributed under
the Creative Commons Attribution 4.0 License.
Regular research article
23 Feb 2018
Design and evaluation of split-ring resonators for aptamer-based biosensors
Tobias Reinecke1, Johanna-Gabriela Walter2, Tim Kobelt1, André Ahrens1, Thomas Scheper2, and Stefan Zimmermann1 1Leibniz Universität Hannover, Institute of Electrical Engineering and Measurement Technology, Department of Sensors and Measurement Technology, Appelstr. 9A, 30167 Hanover, Germany
2Institute of Technical Chemistry, Leibniz Universität Hannover, Callinstr. 5, 30167 Hanover, Germany
Abstract. Split-ring resonators are electrical circuits, which enable highly sensitive readout of split capacity changes via a measurement of the shift in the resonance frequency. Thus, functionalization of the split allows the development of biosensors, where selective molecular binding causes a change in permittivity and therefore a change in split capacity. In this work, we present a novel approach using transmission line theory to describe the dependency between permittivity of the sample and resonance frequency. This theory allows the identification of all relevant parameters of a split-ring resonator and thus a target-oriented optimization process. Hereby all setup optimizations are verified with measurements. Subsequently, the split of a resonator is functionalized with aptamers and the sensor response is investigated. This preliminary experiment shows that introducing the target protein results in a shift in the resonance frequency caused by a permittivity change due to aptamer-mediated protein binding, which allows selective detection of the target protein.

Citation: Reinecke, T., Walter, J.-G., Kobelt, T., Ahrens, A., Scheper, T., and Zimmermann, S.: Design and evaluation of split-ring resonators for aptamer-based biosensors, J. Sens. Sens. Syst., 7, 101-111,, 2018.

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Short summary
A systematic investigation of a split-ring resonator for application as a biosensor is presented. The parameters responsible for the sensitivity of the setup were determined using a new approach to determine the resonance frequency depending on the relative permittivity of the sample. Based on these parameters, the resonator structure was optimized. Subsequently, a split-ring resonator was functionalized with aptamers and a selective detection of CRP could be shown.
A systematic investigation of a split-ring resonator for application as a biosensor is...